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PH-release mesalamine exhibits comparable remission rates after forty eight weeks of treatment compared with sulfasalazine (sixty two% vs 61%, p > 0.ninety) ( Riley et al 1988b ). However, pH-launch mesalamine had decrease 12-month remission upkeep rates than olsalazine in a separate examine ( Courtney et al 1992 ). Whereas information extrapolated from earlier scientific trials have recommended superior clinical response charges with larger doses of pH-release mesalamine, the recent large ASCEND-1 trial found no clear dose-associated benefit between daily doses of 2.4 g vs four.8 g in the treatment of delicate-to-average UC, although the ASCEND-2 trial showed a benefit in response, but not remission, with the 4.eight g dose in sufferers with reasonably extreme illness ( Hanauer et al 2005 ). The commonest side-results related to pH-dependent launch mesalamine in a 6-month examine had been headache, flu signs, diarrhea, rhinitis, and belly pain ( The Mesalamine Research Group 1996 ).
Esomeprazole; Naproxen: (Main) The dissolution of the coating on mesalamine extended-launch capsules (Apriso) and the delayed-launch tablets (Lialda) depends on pH. Avoid coadministration with medication that raise gastric pH like proton pump inhibitors.
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